Ask an answerable question (PICO)：
In order to alleviate the symptoms of rheumatoid arthritis, such as inflammation and joint pain, in addition to general drug treatment, the literature pointed out that the main component of fish oil, Omega-3 unsaturated fatty acids, can improve the inflammatory response, thereby relieving the patient's Therefore, it is an idea to explore whether taking Omega-3 unsaturated fatty acid supplements can relieve the pain of rheumatoid arthritis in an empirical way, so as to provide rheumatoid patients with dietary therapy in addition to drug therapy. We expect to explore an evidence providing effective relief of pain in rheumatoid arthritis through the empirical results of this book report ways to improve the quality of life in rheumatoid arthritis.
The Method and Analysis of Literature Review：
Using evidence-based medicine steps, the PICOs are P: "Rheumatoid Arthritis (Rheumatoid Arthritis) Arthritis)"; I: "Omega-3 polyunsaturated fatty acids (Omega-3 polyunsaturated fay acids)"; C: "placebo, conventional treatment"; O: "arthritis pain (arthritic pain)", using Bollinger logic and limiting the following criteria, Humans, Systematic Review or Randomized Controlled Trial, and the age limit of the article is from January 2017 to September 2022. Adult and English-written literature are included. Finally, there are 52 articles in the database search, which are screened by the PRISMA flow chart process to exclude duplication and Articles that do not meet the requirements will be included in one SR literature for strict review.
Critical Appraisal：
The Systematic Review Critical Appraisal Sheet, CEBM University of Oxford, 2010 was used as the evaluation tool for strict evaluation, and the evidence level was evaluated by the Oxford Center Level of Evidence2011. The evidence level of this SR literature is Level 1. The evaluation results of the quality of the literature in each item " What question (PICO) did the systematic review address?", " Is it unlikely that important, relevant studies were missed?", " Were the criteria used to select articles for inclusion appropriate?", " Were the included studies sufficiently valid for the type of question asked?", "Were the results similar from study to study?" are all 「YES」.The results of the study on the overall effect of oral unsaturated fatty acid supplementation on inflammatory rheumatic disease activity parameters, pain scale-visual analogue scale (VAS): SMD, -0.53 (95% CI, [-1.05 to -0.01]); heterogeneity assessment I2 = 93%; p < 0.001, high heterogeneity with significant differences.
Results, Conclusions and Recommendations：
The results of the literature review confirmed that for patients with rheumatoid arthritis, adding Omega-3 unsaturated fatty acid supplements to conventional treatment for three months can improve joint pain. Since fish oil is a food supplement and is easily available, it is widely accepted by the Taiwanese people. It is suggested that the literature evidence can be applied to the adjuvant therapy for pain relief of cancer patients.
