Ask an answerable question (PICO)：
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect, which can lead to numbness in the hands and feet and impair the quality of life of patients after chemotherapy. These can also delay treatment completeness and eventually lead to increased public health expenditure. Our unit is a surgical ward. CIPN is commonly seen in patients with breast cancer who needed chemotherapy. Some physicians will prepare ice gloves and socks for patients before chemotherapy. Therefore, we wants to explore whether the use of ice pack for breast cancer patients can reduce the incidence of CIPN and search for its level of evidence.Our aim is to improve the quality of care for patients during chemotherapy.
The Method and Analysis of Literature Review：
By searching Cochrane Library, PubMed, CINAHL, Embas, Huayi online library using PICO keywords. A total of 97 articles were found Duplicates, inconsistent themes, inconsistent research designs, and the full text could not be retrieved were excluded. Finally, 4 RCTs were included for review.
Critical Appraisal：
The purpose of the study is to see whether ice gloves and socks can improve the effect of CIPN in breast cancer patients.Enrolled subjects are aged 22 to 66 years old. The study design was a randomized controlled trial. The level of evidence is Level 2 according to the Oxford CEBM recommendation level of Oxford University Centre for Empirical Medicine.
Results, Conclusions and Recommendations：
Literature results: The use of ice pack in breast cancer patients can reduce the peripheral neuropathy caused by chemotherapy. Ice pack includes gloves and socks,to be used 15 minutes before each chemotherapy,and until 15 minutes after the drug was delivered to this intend to minimize,discomfort caused by neuropathy.
