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Expectoration of blood, a common symptom of different lung disease, increases short of breath and results in higher mortality rate. Transamine was a commonly used anti-fibrinolytic agent, has been shown to control bleeding. However, the effects of direct use on pulmonary hemorrhage and the effect is less discussed. The purpose of this study was to investigate the use of transamine to reduce the hospital length of stay and resolution of expectoration of blood in adult patients.
The Method and Analysis of Literature Review：
Our study searched the Cochrane library, Embase, PubMed (including MEDLINE), and the CEPS for randomized clinical trials (RCTs) investigating the effects of transamineon hemoptysis before August 2019. We focused on literature in Chinese and English and followed reference lists for identifying relevant trials.
Two of us individually assessed the study quality by using the Cochrane Risk of Bias (RoB) tool, and pooled results were estimated in the RevMan 5.3 software.Our search identified 447 references, and 4 of them met eligible criteria. The four RCTs recruited 185 patients with hemoptysis. The pooled result showed that no significant differences in resolution expectoration of blood (n=117, Risk Ratio [RR] = 1.36; 95% CI 0.86 to 1.86; I²= 77%) between transaminegroup and control group. However, the pooled estimate showed that transaminedecreased hospital length of stay (n=133, MD = -1.62; 95% CI -2.93 to -0.31; I²= 0%).
Conclusions and Recommendations：
Our meta-analysis indicated that transaminehas shorter hospital length of stay among patients with expectoration of blood. Nevertheless, our evidence involved small sample size trials. We anticipate further large scale RCTs to confirm the effectiveness and safety of transamine.