間時提取訓練是否能改善失智症病人嗜食行為?Can spaced retrieval training improve the eating behavior of patients with dementia?

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2024-08-28 已刊登
綜 整 預防/治療/介入類型

作  者

李淇鳳* 簡淑芬 丁淇平

文章類別

A 類:實證健康照護綜整

問題類型

治療/預防性問題

健康狀況

神經醫學 (Neurology)  

治療/介入措施

臨床護理技術相關措施(Clinical Nursing Skills and Techniques) - 間時提取訓練

專長類別

神經科學暨肌肉骨骼護理

中文關鍵詞

#失智症、間時提取、嗜食、暴食。

英文關鍵詞

#Words : Dementia、Spaced retrieval、Eating、Hyperphagia

機構名稱

長庚醫療財團法人高雄長庚紀念醫院

申請單位

護理部神經內科10D病房

中文摘要

形成臨床提問:
全世界老年人口均快速成長,台灣已於2018年邁入高齡化社會,隨之失智症盛行率增加,成為常見老化問題,更是世界公共衛生主要問題之一。失智症病人因認知功能障礙退化而產生嗜食(暴食)行為,導致進食量及速度增加,不當飲食行為容易導致上呼吸道阻塞、營養失衡或因錯誤飲食引起中毒等風險,如何改善失智症病人嗜食行為,成為重要議題。過去文獻中發現許多研究以「間時提取」訓練方式介入,多數成效結果顯示可改善認知功能及記憶力,但鮮少提及是否改善嗜食行為成效仍未有所定論,筆者於神經內科病房臨床服務,屢見失智症病人嗜食行為造成照顧者困擾增添照顧負荷,有感於此本文希望了解「間時提取訓練是否可改善失智症病人嗜食行為?」,期望藉由實證文獻探討深入了解成效進而運用於臨床照護。
文獻搜尋的方法與分析:
本文依據實證五A之前三步驟(asking, acquire, appraisal),形成 PICO:「間時提取訓練是否可改善失智症病人嗜食行為?」,關鍵字設【P】失智症病人Dementia、Alzheimer Disease 【I】間時提取訓練Spaced retrieval【C】一般常規治療Routine 【O】嗜食行為Eating、Overeat、Hyperphagia。利用 MeSH term、自然語言、同義詞設定之中英文關鍵字,搜尋華藝線上圖書館、 PubMed/MEDLINE、Cochrane Library、Embase、CINAHL共五個中英文資料庫,運用布林邏輯之OR聯集及AND交集進行,納入條件為2016年4月至2022年11月)、不限定語言、研究類型以系統性文獻回顧(Systematic review, SR)及統合分析(Metanalysis, MA)為優先,其次為隨機對照試驗(Randomized controlled trial, RCT)的文獻。搜尋得出共26篇,刪除重複內容及結果不符,最後遴選1篇SR及2篇RCT共3篇進行評析。
文獻的品質評讀:
使用2018年中版及2020年英文版CASP(Critical APPraisal Skills Program)為工具,進行有效性、重要性及應用性之評析。依Oxford Centre for Evidence- Based Medicine 2011 Levels of Evidence的臨床研究證據等級分類,三篇研究文獻皆探討間時提取訓練對於輕、中度認知障礙失智症病人嗜食行為之成效,收案對象皆為社區失智病人與PICO所設立研究目的及對象相同。一篇文獻SR評析屬於Level 1,二篇文獻RCT評析屬於Level 2,整體三篇文獻皆是高品質研究,可應用於臨床參考。
結果、結論與建議:
本文以實證手法統整過去研究結果顯示介入間時提取認知行為訓練,並未產生不良事件,是一種安全得介入措施。在臨床上用間時提取訓練來教導記憶學習,可促進透過行為訓練取代藥物治療,控制失智症病人嗜食行為,從中學習養成日常生活良好習慣,無形中提升用餐禮儀。整體而言,3篇研究結果皆支持間時提取認知訓練屬非侵入性治療且安全,可改善失智病人嗜食行為,讓失智症病人更容易牢記相關訓練,落實日常實踐任務是更大的價值,但是文獻提及間時提取訓練只適用於輕中度病人,因此執行間時提取訓練應考量失智症病人認知障礙之嚴重程度以利臨床應用。

英文摘要

Ask an answerable question (PICO):
The elderly population is rapidly growing worldwide, and Taiwan entered an aging society in 2018. Dementia patients often develop eating disorders due to cognitive decline, elevating risks like respiratory issues, malnutrition, and improper food intake. Improper eating behavior can easily lead to risks such as upper respiratory tract obstruction, malnutrition, or poisoning due to incorrect food intake. Therefore, how to improve the eating behavior of patients with dementia has become a crucial issue. In previous literature, many studies have found that intervention using spaced retrieval training can improve cognitive function and memory. However, there is little consensus on whether it can improve eating behavior. Therefore, the authors were guided by the question of "Can spaced retrieval training improve the eating behavior of patients with dementia?" and hoped to gain a better understanding of the effectiveness through empirical literature exploration.
The Method and Analysis of Literature Review:
According to the three steps of evidence-based practice (asking, acquire, appraisal), the present study formed a PICO question: "Can spaced retrieval training improve the eating behavior of elderly patients with dementia?" The keywords were set as follows: P: elderly patients with dementia; I: spaced retrieval training; C: standard care; O: eating behavior. Five databases, including the China Academic Journals Full-text Database, PubMed/MEDLINE, Cochrane Library, Embase, and CINAHL, were searched using MeSH terms, natural language, and synonyms in both Chinese and English. The Boolean logic of AND and OR was used to combine the keywords. The inclusion criteria were from April 2016 to November 2022, no language restrictions, and the study types were systematic reviews (SR) and meta-analyses (MA) as a priority, followed by randomized controlled trials (RCT). A total of 26 articles were initially identified, and duplicates and irrelevant results were removed. Finally, one SR and two RCTs were selected for critical appraisal.
Critical Appraisal:
Using the 2018 Chinese version and 2020 English version of the Critical Appraisal Skills Programme (CASP) as tools, we conducted an appraisal of effectiveness, importance, and applicability. According to the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence classification of clinical research evidence, all three studies investigated the use of spaced retrieval training for mild to moderate cognitive impairment, and the participants were all community-dwelling individuals with dementia, consistent with the PICO research question and target population. The three appraisals belong to Level 1 and Level 2, and the study results support the effectiveness of spaced retrieval cognitive training in improving the eating behavior and meal etiquette of people with dementia. All three articles are of high quaility research and can be applied for clinical reference.
Results, Conclusions and Recommendations:
This study's methodology was comprehensive, and past research has shown that intervention using spaced retrieval cognitive training does not result in adverse events and is a safe intervention. In clinical practice, using spaced retrieval training to teach memory and eating learning can promote the use of non-pharmacological behavior training instead of medication, control the eating behavior of patients with dementia, and learn to develop good daily habits, which can improve dining etiquette indirectly. Therefore, spaced retrieval training program should be applied for clinical reference. However, when implementing spaced retrieval training, the severity of cognitive impairment in patients with dementia should be considered for appropriate clinical application.