Ask an answerable question (PICO)：
Chemotherapy is the main treatment for anti-cancer therapy. With the accumulation of chemotherapy doses in the body, the symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN) become more and more obvious. Many research results showed that treatment combined with non-pharmacological interventions have potential benefits for improving CIPN. In the non-pharmacological interventions, exercise programs have more advantages, such as being able to be carried out at home, without special medical equipment, and low cost. Therefore, this article aims to explore through empirical methods whether the exercise could improve the CIPN of chemotherapy patients.
The Method and Analysis of Literature Review：
According to the established keywords and MeSH terms were used to search for articles from electronic databases including Airiti Library, National Digital Library of Theses and Dissertations in Taiwan, The Cochrane Library, PubMed, and MEDLINE. A total of 3 articles published before November 2021 met the search criteria.
Critical Appraisal：
By the evidence levels of the 2011 Oxford Centre for Evidence-Based Medicine, 1 article is Level 2 and 2 articles are Level 1 respectively. Research quality was appraised using the CASP-RCT and CASP-SR checklist. The articles are first reviewed by two independent researchers. If there is a disagreement, a third researcher is invited to confirm and discuss until the opinions are the same.
Results, Conclusions and Recommendations：
Significant improvements were detected on CIPN symptoms and balance in all 3 articles. It can be applied to all cancer patients who received chemotherapy and exercise can be started at the beginning of treatment. The type of exercise is not specific, such as yoga, aerobic, strength, resistance, core stability, sensorimotor training, and balance training can be selected according to personal preferences. Multimodal training as aerobic combined strength or balance training was encouraged.
The resistance exercise with elastic bands was the most popular intervention recently. In addition, jogging, walking, cycling, riding a spinning bike, and swimming are all common aerobics that could be chosen according to patients’ preferences or habits. Moderate intensity (50%-80% of maximum heart rate) for exercise should be suggested with a frequency at least 3 times per week, 100 minutes a week, and durations more than 8 weeks.
