Ask an answerable question (PICO)：
Rotavirus have wheel shapes in microscope .As a high virus due to "high infection rate", "high rate of medical treatment" and "high hospitalization rate".Rotavirus is the main cause of severe diarrhea and dehydration from 6 months to 2 years age children. It’s the most susceptible to infection about 95% of children within2 years of age. Taiwan is not included in the routine vaccine program, must be purchased at their own expense. Parents ask “Does the vaccine safe?”“ What are the side effects?” Then,the group of patient is child, the intervention is rotavirus vaccines, the outcome is diarrhoea、gastroenteritis、intussusception、death、adverse event.Therefore, the empirical results can be used as the basis for the clinical medical staff, and parents choose the reference.
The Method and Analysis of Literature Review：
The keywords include Infant, children、Newborn、child、rotavirus vaccines、Rotavirus、Rotavirus Infections、diarrhoea、gastroenteritis、intussusception、death、adverse event. Boolean logical AND and OR, searching for databases such as Cochrane, PubMed, and Huayi (CEPS). The search time is August 2019, and the conditions are 5 years old. And Chinese and English literature, a total of 867 articles were searched, and 422 articles of repeated articles were deleted according to the title, and then the title and abstract were selected to exclude 443 articles that did not meet the inclusion criteria, of which 55 RCT studies were included in one of them. In the SR study, 203 ethnic groups were not limited to young children, 115 interventional non-rotavirus vaccines, and 70 studies were completely unrelated to this topic. Then, the text was screened and excluded from the article. Since the intervention is not only a rotavirus vaccine, the last one is the Vaccines for preventing rotavirus diarrhoea: vaccines published by Soares-Weiser, K. et al. in 2019. In use systematic literature retrospective article.
Critical Appraisal：
This article uses Systematic Review Appraisal Sheet (University of Oxford, 2010) to conduct a rigorous review of a systematic analysis of 2019. The rating is Level I.
This article included 55 RCT experimental studies in a total of 216,480 participants. Of these, 36 (119,114 participants) evaluated RV1; 15 (88,934 participants) evaluated RV5; and 4 (8,432 participants) evaluated Rotavac. The evaluation comparison items included the incidence of intussusception, the incidence of diarrhea, the incidence of adverse events, and mortality.
Results, Conclusions and Recommendations：
According to literature statistics, the preventive effect of Rotary Rotavirus vaccine (Rotarix RV1) was 84% in the first year and 82% in the second year. The incidence of side effects was 0.1% and the fever was 32.2%. Vomiting was 32.2%. The incidence of diarrhea was 0.2% after 1 year and 0.4% after 2 years. Rotateq RV5 has a preventive effect of 92% in the first year and 82% in the second year. After taking the side effects, the incidence of intussusception is 0.04%, fever is 34.9%, and vomiting is 34.9%. The incidence of diarrhea was 3.6% after 1 year and 2.5% after 2 years. Rotavac: In countries with high mortality rates, such as India, prevention of rotavirus-induced severe diarrhea is about 50%. (Moderate level of evidence), prevention of severe diarrhea caused by all causes in India is about 18%. (Moderate level of evidence), a randomized controlled trial of this vaccine has not been available in countries with low mortality.
The results of the study showed that both RV1 and RV5 preparations had more than 80% prophylaxis after administration. It is recommended that infants use oral vaccines against rotavirus to form antibodies that block rotavirus invasion in vivo.
